Born in Catania, Italy, on eight September 1984, he showed an inclination for music from an early age, in fact he began studying classical guitar at the age of eight. As a child, he won numerous classical guitar competitions, even making his debut as a soloist. His talent was so evident that he was considered an enfant prodige in the classical guitar world.

At the age of fourteen, he temporarily left the guitar to devote himself to electronic music.

Immediately after high school, at the age of nineteen, he discovered Jazz, which was to become his main channel of expression. He immediately made his mark in the Sicilian jazz scene before attending the Umbria Jazz Clinics in Perugia in 2006. There he was able to participate in prestigious masterclasses held by internationally renowned professors and musicians as well as professors from the prestigious Berklee College Of Music in Boston, such as: Ken Cervenka, Ron Savage, Dennis Montgomery III, Donna McElroy, David Clark, Michael Williams, David Howard, Sheryl Bailey, Suzanna Sifter, James Odgren and Larry Monroe and Bruno Tommaso.
In 2007, through the Siena Jazz foundation, he won a scholarship to represent Italy at the IASJ (International Association Schools of Jazz) in Riga, Latvia. Here he took part in advanced courses with Claudio Fasoli, Pietro Condorelli, Paolino Dalla Porta, Enrico Rava, Tommaso Lama and Giovanni Mayer.
That same year, during Siena Jazz, he was noticed by trumpeter Enrico Rava who decided to involve him on tour with his band Enrico Rava Special Edition, Rava would soon say of Claudio:
  "A truly incredible guitarist, I don't think I have ever heard one like him in Italy, his name is Quartarone, he is from Catania, like Francesco Cafiso, that area is giving monstrous musicians".
In 2008, he began collaborating with the RAI TRADE label (RAI's label), which would see the release of the three albums Even Eight, The Third Boss Guitar, Elevator .

In 2010 he opened the concert for Paolo Fresu and Omar Sosa at Catania's Metropolitan Theatre.
In 2011, the Comar23 label produced and distributed Quartarone's new album entitled Subliminal .
From 2011 to 2016 he released a large number of digital releases ranging from jazz to electronic contamination, experimenting with new forms of musical communication and collaborating with Video Artists. Always in search of new languages in the contemporary music world.
In 2015, he created the music for the DVD inspired by Napoleon Hill's international best seller Think and Grow Rich entitled Think and learn big produced and promoted by the US-based Napoleon Hill Foundation.
In the same year, a track from the album Calling Any Station was selected as the soundtrack for the VOR brand commercial.
The press on Claudio Quartarone is numerous and unanimously defined as an extraordinary talent, he is also mentioned in the most important Italian jazz culture sites, newspapers and magazines: JAZZIT, JazzEspresso, All About Jazz, JazzItalia, Guitar Club Magazine, Neuguitars.
In January 2018 he published his first book entitled "Method for improvising guitarists" published by Workin'Label productions.
For the same label in May 2018 he released a new album entitled Changes , performed entirely on solo guitar.
In March 2019, a new album, Equilibrium , is released in all digital stores.
Among other achievements, the Australian company Valiant Samples , built a plug-in based on Claudio's electric sound called Quartarone Guitar Reveries . This instrument has been used by Burkhard Dallwitz and other great composers.
During his career he plays with some of the most important musicians of the national and international jazz scene including: Francesco Cafiso, Enrico Rava, Yussef Dayes, Rocco Palladino, Umberto Fiorentino, Daniele Tittarelli, Fabrizio Sferra, Giovanni Guidi, Mauro Ottolini, Stefano Senni, Dino Rubino, Dan Kinzelman, Andrea Beneventano, Joao Lobo, just to name a few.
-2022 work on the Anamorfosi project together with Umberto Fiorentino for Birdbox Records different styles and influences unite two uniquenesses, which in turn become, extraordinarily, one.