An organist with a broad interpretative horizon, spanning from the Renaissance to the present day, Livia Mazzanti is also an improviser, an art passed on to her by Giacinto Scelsi in Rome, then by Jean Guillou, with whom she perfected her skills at length in Paris.
Her recordings of works by Schoenberg, Busoni, Hindemith, Scelsi, Guillou, and the rediscovery in world premiere of the organ integrals by Rota and Castelnuovo-Tedesco, are considered landmarks; she has recorded for Fonè, Rca Victor/BMG France, Philips Classic, Argos, Stradivarius, Aeolus, Continuo.
Her concerts have taken her everywhere in Europe (guest of prestigious seasons such as the Bath Festival, the Europalia Festival in Brussels, the Festival d'Orgue de Saint-Eustache in Paris, the Sagra Musicale Umbra, the Organ Cycle of the Philharmonie in Berlin...), as well as in the United States, South America and the Middle East. Since 1995, she has directed the MUSICOMETA international festival in Rome, which she created, and collaborates with the Christuskirche.

Livia Mazzanti is the dedicatee of pieces for organ by current composers, and has interacted with the contemporary art world on several occasions.